The Editors welcome submissions for possible publication in the Letters section. Authors of letters should: Include no more than 300 words of text, three authors, and five references Type with double-spacing Send three copies of the letter, an authors' form see Table of Contents for location ; signed by all authors, and a cover letter describing any conflicts of interest related to the contents of the letter Letters commenting on an Annals article will be considered if they are received within 6 weeks of the time the article was published. Only some of the letters received can be published. Published letters are edited and may be shortened; tables and figures are included only selectively. Authors will be notified that the letter has been received. If the letter is selected for publication, the author will be notified about 3 weeks before the publication date. Unpublished letters cannot be returned. Annals welcomes electronically submitted letters. The Internet address is : acponline journals annals letters.
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Similar reports have been released in countries other than Japan. In one of them, a group of subjects receiving a drug therapy containing DSCG saw a dramatic decrease in the number of emergency visits and or hospitalizations compared with a group of subjects receiving a drug therapy not containing DSCG. The authors concluded that a drug therapy containing DSCG was cost-effective Ross N et al., Clin Ther 10 2 ; : 188203, 1988 ; . No studies have been carried out from the perspective of the correlation, for example, prozac overdose.
Good Oncophage HSPCC-96, HSP based While encouraged by the announcement that cancer vaccine ; data in RCC, Melanoma, the EORTC and AGEN plan to initiate a 9CRC all PhII ; and Pancreatic Cancer PhI ; , month Oncophage Melanoma study in early 1 ; have shown clinical efficacy and 2 ; '04, we remain cautious on the signals this support predicted molecular mechanisms initiative could send until we learn more on cancer-specific immune response ; beyond trial design Melanoma is extremely tough to treat ; . proof of principle. Key Oncophage milestones over the next two Investors may react negatively to interim data quarters include 1 ; interim data from from the PhIII Oncophage trial in RCC early ongoing PhIII RCC trial in early 1Q04 and 1Q04 ; . We conservatively expect positive 2 ; PhII data at ASH in low-grade NHL trend data vis--vis a statistically significant segregation of survival curves. positive based on ASCO ; . AGEN remains well financed for the time Although clearly showing clinical successes, being. With ~$2.3m in annual revenues from the cancer vaccine space continues to be Leucogen feline leukemia, divestiture viewed as high risk by the investors. AGEN expected ; , AGEN should enter '04 with has attempted to diversify risk with multiple ~$90m in cash, sufficient for operations into products in advanced clinical developments; 1Q05 at current burn $65m annually ; . In but for the time being, the focus on '03 AGEN filed an S3 $100m ; and issued Oncophage essentially makes this stock a $31.4m in convertibles to a private investor, "one drug story". leaving the company with an option to raise one year of additional cash. News flow over the next two quarters includes 1 ; AG-858 HSP-based therapeutic ; PhII data in combination with Gleevec for CML at ASH, 2 ; initiation of additional Oncophage PhI II trials in Breast and Lung Cancer YE03 ; and 3 ; two IND filings by 1Q04 AG707 genital Herpes vaccine and 2nd generation Oncophage ; . Strong management team.
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6: A1. Publication No. : 96035 ; Tao A.W.K., Wat N.M.S., Xu A., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene T45G polymorphism is associated with central obesity and glucose intolerance in southern Chinese, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004. Publication No. : 88415 ; Ting K.H., Shen M.F., Fung P.C.W. and Chan F.H.Y., Multi-channel Fourier Packet Transform of EEG: Optimal Representation and Time-Varying Coherence, IEEE-EMBS-APBME 2003 Asian-Pacific Conference on Biomedical Engineering. Kyoto-Osaka-Nara, Japan, IEEE, 2003, 120-121. Publication No. : 95131 ; Ting K.H., Shen M., Fung P.C.W. and Chan F.H.Y., Multi-channel fourier packet transform of EEG: optimal representation and time-varying coherence, Proceedings of IEEE-EMBS-APBME 2003 Asian-Pacific Conference on Biomedical Engineering, Kyoto-Osaka-Nara, Japan. 2003. Publication No. : 96199 ; Ting K.H., Chang C., Leung A., Chan C.C.H., Fung P.C.W. and Chan F.H.Y., Second Order Statistics Based Blind Source Separation for Artiface Correction of Short ERP Epochs, IEEE-EMBS-APBME 2003 AsianPacific Conference on Biomedical Engineering. Kyoto-Osaka-Nara, Japan, IEEE, 2003, 186-187. Publication No. : 95132 ; Ting K.H., Chang C., Leung A.W.S., Chan C.C.H., Fung P.C.W. and Chan F.H.Y., Second order statistics based blind source separation for artifact correction of short ERP epochs, Proceedings of IEEE-EMBS-APBME 2003 Asian-Pacific Conference on Biomedical Enginerring, Kyoto-Osaka-Nara, Japan. 2003. Publication No. : 96202 ; Ting K.H., Qiu W., Shen M.F., Fung P.C.W. and Chan F.H.Y., Tracking P300 in Single-Trial Oddball ERP with Adaptive Filtering and Radial-Basis-Function Network, World Congress on Medical Physics and Biomedical Engineering. Sydney, Australia, IFBME, 2003, 4 pages. Publication No. : 95130 ; Ting K.H., Qiu W., Shen M., Fung P.C.W. and Chan F.H.Y., Tracking P300 in single-trial oddball ERP with adaptive filtering and radial-basis-function network, Proceedings of WC2003 World Congress on Medical Physics and Biomedical Engineering, Sydney, Australia. 2003. Publication No. : 96188 ; Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Ho J.C.M. and Lam W.K., Central microtubular ciliary defects are of clinical significance in bronchiectasis, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-20: p.199. Publication No. : 87415 ; Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Ho J.C.M. and Lam W.K., Ciliary central microtubular orientation is of no clinical significance in bronchiectasis, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-21: p.200. Publication No. : 87416 ; Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C. and Lam W.K., Clinical significance of ciliary abnormalities in bronchiectasis, European Respiratory Journal. 2003, suppl 22 45 ; : P559. Publication No. : 88215 ; Tsang K.W.T., Ho P.L., Tan K.C., Ooi C.G.C., Ho J.C.M., Tipoe G.L., Lam W.K. and Chan M.M.W., Efficacy of 12-month treatment with inhaled corticosteroid in bronchiectasis, European Respiratory Journal. 2003, suppl 22 45 ; : P3213. Publication No. : 88218 ; Tsang K.W.T., Gold standards for SARS and clinical diagnostic models, Abstract Book of Hong Kong Health Authority Convention, May. 2004, 42. Publication No. : 88226 ; Tsang K.W.T., Tipoe G.L., Sun J.Z., Leung Y.H., Ho P.L., Yuen K.Y., Mak J.C.W. and Lam W.K.
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Department of Epidemiology and Preventive Medicine, Monash Medical School, Alfred Hospital, Victoria; Department of Respiratory Medicine, Alfred Hospital, Victoria. MacDonald Research Laboratory, St Paul's Hospital, Vancouver, Canada; Instituto di Fisopatologia, Italy; Faculty of Medicine, University of Calgary, Canada; MacDonald Research Laboratory, St Paul's Hospital, Vancouver, Canada; MacDonald Research Laboratory, St Paul's Hospital, Vancouver, Canada; Department of Pathology, Sao Paulo University Medical School, Brazil MacDonald Research Laboratory, St Paul's Hospital, Vancouver, Canada; Henry Wellcome Building for Human Genetics, Oxford University, England; Oregon Regional Primate Research Centre, Oregon, USA.
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Page 4 CURRICULUM VITAE Arthur J. McCullough, M.D. Reviewer for Scientific Journals: AHFS Drug Information American Journal of Gastroenterology American Journal of Physiology Annals of Internal Medicine Digestive Diseases and Sciences Drugs European Journal of Gastroenterology and Hepatology Gastroenterology GUT Hepatology International Journal of Psychiatry in Medicine Journal of Clinical Investigation Journal of Hepatology Journal of Laboratory and Clinical Medicine Journal of Parenteral and Enteral Nutrition Mayo Clinic Proceedings.
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Spasticity, depression, fatigue and urinary, paroxysmal and sensory symptoms can all be alleviated to some extent with pharmacological interventions, although rehabilitation procedures and psychosocial consultations are no less important and
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Classical serotonin transporter, we tested the effects of SSRIs comprising several different antidepressants that can reduce or abolish SLC6A4 activity. One such widely used SSRI, fluoxetine Prkzac ; , was found to inhibit 5-HT uptake by MII oocytes in a dose-dependent manner with a calculated IC50 of 355 nM Fig. 5D ; , confirming the involvement of a classical serotonin transporter. Similarly, another SSRI, fluvoxamine Luvox ; , was even more potent in suppressing 5-HT uptake with a calculated IC50 of 6 nM Fig. 5E ; . These inhibitions were reversible upon washing of the cells Fig. 5F ; , and active SSRI concentrations were in the usual range of specificities reported in other cells [26]. Control oocytes incubated in fluoxetine or fluvoxamine alone without added 5-HT displayed fluorescence levels not statistically different from those of untreated oocytes Fig. 5F ; . We also detected endogenous 5-HT in fourcell stage embryos and 4-day-old blastocysts Fig. 6, AA and DD , shows phase contrast and corresponding immunofluorescence images ; . Embryo labeling with the anti5-HT antibody was also enhanced when the embryos were preincubated in medium containing 500 nM 5-HT for 20 min Fig. 6, B and E ; . No cell labeling was found when.
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Seeman, T. E., Jul-Aug, 2000 ; . Health promoting effects of friends and family on health outcomes in older adults. American Journal of Health Promotion. 14 6 ; : 362370. Sirey, J.A., Bruce, M.L., Alexopoulos, G.S. Perlick, D. A., Raue, P., Friedman, S. J., & Meyers, B. S. March. 2001 ; . Perceived stigma as a predictor of treatment discontinuation in young and older outpatients with depression. American Journal of Psychiatry. 158 3 ; : 479-481. Sonnenberg, C.M., Beekman, A.T.F., Deeg, D.J.H. & van Tilburg. W. 2000 ; . Sex differences in late life depression. Acta Psychiatrica Scandinavica. 101 4 ; : 286-292. Spencer, C. 2003 ; . Seniors and Alcohol. Online at: agingincanada Turkington, C. & Kaplan, E, 1997 ; . Making the Lrozac Decision, RGA Publishing. Online at: my md content article 3 1680 50554 Uncapher, H. & Arean, P.A. Feb. 2000 ; . Physicians are less willing to treat suicidal ideation in older patients. Journal of the American Geriatrics Society. 48 2 ; 188-192. Untzer, J., Katon, W., Callahan, C. M., Williams, J. W. et al. December 11, 2002 ; . Collaborative Care Management of Late-Life Depression in the Primary Care Setting JAMA. 288: 2836-2845. van Marwijk, H.W., Wallace, P., de Bock, G.H., Hermans, J., Kaptein, A.A., & Mulder, J.D. April, 1995 ; . Evaluation of the feasibility, reliability and diagnostic value of shortened versions of the geriatric depression scale. British Journal of General Practice, 45 393 ; : 195-9. Visser, P.J., Verhey, F.R.J., Ponds, R.W., Kester, A. , & Jolles, J. May 2000 ; . Distinction between preclinical Alzheimer's disease and depression. Journal of the American Geriatrics Society. 48 5 ; : 479-484. Watt, L. M. & Cappeliez, P. May, 2000 ; Integrative and instrumental reminiscence therapies for depression in older adults: intervention strategies and treatment effectiveness. Aging and Mental Health. 4 2 ; : 166-177 and
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Initial samples will be collected at a point upgradient i.e., upstream, upwind ; from the source area, at three locations along the early sentry arc and at three locations along the late sentry arc. MC detected in the sentry area at concentrations above screening values See section 4.4.1 ; indicate a need for a more detailed evaluation of release parameters including migration rate estimation ; and additional sampling beyond the sentry area e.g., at or near the range boundary ; . Installation of monitoring wells and collection of soil and or surface water samples at the range boundary may be necessary to determine whether or not actual off-range migration of MC has occurred. 4.3.3 Sampling Plan Development Prior to initiation of field sampling, a Sampling and Analysis Plan SAP ; and a Quality Assurance Project Plan QAPP ; must be prepared. The SAP and QAPP should follow applicable USAF standards and include details regarding sampling approach, methodology, MC, analytical parameters, and laboratory specifications. Both plans should be included in the Qualitative Assessment Report when the qualitative assessment indicates the need for a quantitative assessment. 4.3.4 Analytical Requirements Analyses of media for MC must be performed by a laboratory qualified to perform the methods identified for each analyte in Table 4-3. The list of analytes will mirror the list of MC developed, because know need prozac.
6 July 2002 ; , ftc.gov os 2002 07 genericdrugstudy "FTC Generic Drug Study" ; . Generic competition following successful patent challenges to Prozac, Zantac, Taxol, and Plantinol alone is estimated to have saved consumers more than $9 billion.2 These savings result from the pricing policies of generic sellers, which generally price at a substantial discount from branded drugs. As a result of such price competition, as well as the policies of public and private health plans and state laws that encourage the use of generic drugs, branded drugs lose an average of 44 percent of their sales within the first full year after launch of a lower-priced generic product.3 2. Respondent Schering-Plough Corp. "Schering" ; markets "K-Dur 20, " a potassium supplement generally taken in conjunction with drugs for high blood pressure or congestive heart disease. See Pet. App. 2a-4a, 48a-52a. At the time of the subject agreements, K-Dur 20 was the most frequently prescribed potassium supplement, with annual sales reaching $170 million by 1997. The active ingredient in K-Dur 20, potassium chloride, is in common use and is unpatentable. Schering owns a formulation patent "the '743 patent" ; that relates to the material that coats the potassium chloride crystals, providing an extended-release mechanism. The '743 patent expires in 2006. Thus, a generic manufacturer can use the active ingredient in K-Dur 20 without infringing Schering's patent, so long as it uses a coating material not covered by the '743 patent and
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PA holders are reminded of the implementation of the ICH guideline Q3C on residual solvents which came into effect for new products containing new active substances ; in March 1998. The guideline defines the following classes of solvents : Class 1: solvents to be avoided Class 2: solvents to be limited Class 3: solvents with low toxic potential The classification and the limits for the individual solvents described in the ICH CPMP guideline on Residual Solvents are based on safety considerations. There is therefore no reason why these limits should apply only to new active substances and new medicinal products but not to other products on the market. The CPMP therefore decided that the application of this guideline should be progressively extended to all products in accordance with the following timelines: March 1998 New marketing authorisation for new product containing new active substance ; July 2000 New marketing authorisation for new product containing established active substance ; Marketed Products and
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Non-users. The study was the latest in several reports based on a cohort of about 1000 people born in Christchurch over a four-month period in 1977. An effective way to deal with cannabis use would be to incrementally reduce penalties and carefully evaluate its impact, Fergusson said. 'Reduce the penalty, like a parking fine. You could then monitor the impact ; after five or six years. If it did not change, you might want to take another step.' Source: Bleakley, Louise, "NZ Study Used in UK Drug Review, " The Press Christchurch, New Zealand: March 22, 2005 ; , from the web at : mapinc newscsdp v05 n490 a08 , last accessed March 28, 2005 and
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Functions.Gain-of-functionmutationsoftheCaSRreduceserum 53, 54 ; , causing variablysymptomatichypocalcemia 5557 ; withlowserumPTHlevels 58 ; Table1 ; , ROMK ; 59, 60 ; . Familial hypomagnesemia with hypercalciuria and nephrocalcinosis. Paracellin-1, amemberoftheclaudinfamily 61, 62 ; foundonlyin theTALandDCT, isessentialfornormal, defectsdevelophypomagnesemia, hypercalciuria, polyuria, nephrocalcinosis, stones, distalrenaltubularacidosis dRTA ; , andrenal failure Table1 ; 63 ; . Soluble adenylyl vertebralbonemineraldensity, Reedetal. 64 ; identifiedlinkageto alocusonchromosome1 1q23.3q24 ; .Inaspecificgene human.
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