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Headquarters General Motors Corp. 300 Renaissance Center, P.O. Box 300, Detroit, Mich. 48265-2000 Phone: 313 ; 556-5000. Notes General Motors announced in late 2000 it would phase out its unprofitable Oldsmobile Division to focus on other brands. The phaseout will cover several years, either at the conclusion of the current model lineup product cycle or when models no longer are economically viable. GM noted Olds, a more than 100-yearold brand, had failed to woo enough younger, import intenders to justify sustaining the brand. The company is shifting its Olds advertising from brand-focused to promotional, and has extended warranties on new Olds from three years or 36, 000 miles to five years or 60, 000 miles. The phase-out resulted in an aftertax charge of $939 million in fourth quarter 2000. The "communications" portion of the "auto, communications" segment includes contributions of $7.29 billion in sales and $5.56 billion for 2000 and 1999 from Hughes Electronics, most of which is from its DirecTV unit. Currently courting the unit for possible acquisition are News Corp. and EchoStar. GM in October 2000 began extended negotiations with Daewoo Motor Co. to buy certain assets. Previous bids from DaimlerChryler in concert with Hyundai Motor Co. ; and Ford Motor Co. to buy outright Korea's second-largest automaker met with failure. Personnel, brands, agencies Corporate: John F. Smith Jr., chmn; Rick Wagoner, pres & CEO; Michael Browner, exec dir, media & mktg oper; Steve Harris, VP-comms; John G. Middlebrook, VP & gm-vehicle brand mktg & corp adv; North American Opers: Ron Zarella, exec VP & pres-N. Amer.; Bill Lovejoy, grp VP-GM N. Amer. vehicle sls, svc & mktg; Marissa Sison, dir-adv rsch; Elizabeth Lazar, genl dir, media opers; Denny Bolen, mgr-adv; Candace Robbins, dir-co-op mktg & entertainment alliances; Judy Hu, exec dir, adv & mktg, strategy & opers; Steve Tihanyi, genl dirmktg alliances & regional opers. McCann-Erickson Worldwide, Detroit. Garry Neel, exec VP. D'Arcy Masius Benton & Bowles, Bloomfield Hills, Mich. Patrick Sherwood, mg dir. Chisholm-Mingo Group, New York. Andrea Fant-Hobbs, VP & grp acct dir. Calif. mktg initiative: Manning, Selvege & Lee, Los Angeles. Phil O'Dell, VP & mgmt super, for example, levaquin overdose.
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1 Mylonakis E, Calderwood SB. Infective endocarditis in adults. N Engl J Med 2001; 345: 131830. Moreillon P, Que Y-A. Infective endocarditis. Lancet 2004; 363: 13949. Tornos P, Iung B, Permanyer-Miralda G, et al. Infective endocarditis in Europe: lessons from the Euro heart survey. Heart 2005; 91: 5715. Hoen B, Alla F, Selton-Suty C, et al. Changing profile of infective endocarditis: results of a 1-year survey in France. JAMA 2002; 288: 7581. Vahanian A. The growing burden of infective endocarditis in the elderly. Eur Heart J 2003; 24: 153940. Bouza E, Menasalvas A, Munoz P, et al. Infective endocarditis: a prospective study at the end of the twentieth century--new predisposing conditions, new etiologic agents, and still a high mortality. Medicine Baltimore ; 2001; 80: 298307. Miro JM, del Rio A, Mestres CA. Infective endocarditis in intravenous drug abusers and HIV-1 infected patients. Infect Dis Clin North 2002; 16: 27395. Wilson LE, Thomas DL, Astemborski J, et al. Prospective study of infective endocarditis among injection drug users. J Infect Dis 2002; 185: 17616. Piper C, Korfer R, Horstkotte D. Prosthetic valve endocarditis. Heart 2001; 85: 5903. Delahaye F, Rial MO, de Gevigney G, et al. A critical appraisal of the quality of the management of infective endocarditis. J Coll Cardiol 1999; 33: 78893. Brouqui P, Raoult D. Endocarditis due to rare and fastidious bacteria. Clin Microbiol Rev 2001; 14: 177207. Evangelista A, Gonza lez-Alujas MT. Echocardiography in infective endocarditis. Heart 2004; 90: 6147. Greaves K, Mou D, Patel A, et al. Clinical criteria and the appropriate use of transthoracic echocardiography for the exclusion of infective endocarditis. Heart 2003; 89: 2735. Von Reyn CF, Levy BS, Arbeit RD, et al. Infective endocarditis: an analysis based on strict case definitions. Ann Intern Med 1981; 94: 50517. Durack DT, Lukes AS, Bright DK, and the Duke Endocarditis Service. New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. J Med 1994; 96: 2009. Bayer AS, Bolger AF, Taubert KA, et al. Diagnosis and management of infective endocarditis and its complications. Circulation 1998; 98: 293648. Prendergast BD. Diagnostic criteria and problems in infective endocarditis. Heart 2004; 90: 6113 and levoxyl, for example, levaquin alcohol interaction.
Reference: Tamminga WJ, Wemer J, Oosterhuis B, Wieling J, Wilffert B, de Leij LFMH, de Zeeuw RA, Jonkman JHG. CYP2D6 and CYP2C19 activity in a large population of Dutch healthy volunteers: indications for oral contraceptives-related gender differences. Eur J Clin Pharmacol 1999; 55: 177.
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RESULTS: 20 pts, 17M and 3F, mean age 71.95 8.44, mean Apache score at presentation 13.1 6.47 12 COPD exacerbations ; were studied. While 4 20 positive samples were retrieved from S1, positives rose subsequently to 16 20 for S2 to 10 for S3. Resistant pseudomonas aeruginosa and acinetobacter species accounted for 4 16 and 8 16 for S2 and 5 10 and 5 10 for S3, respectively. In 13 pts antibiotics were changed according to sensitivities. Mortality was high 15 20 ; , especially in nonCOPD pts 8 ; , despite the use of appropriate antibiotics and it was not influenced by the type of bacteria cultured. Comparing concentrations 105 cfu to those with 105 cfu there was no positive correlation with fever 38 C ; or leucocytocis WBC 10500 ; for the group as a whole, as well as for the subgroups of 12 COPD and 8 non-COPD pts. CONCLUSION: Positive cultures of TRBS was a common finding after the first few days in MV MICU pts, with no correlation with fever or leucocytocis. The value of following and treating tracheobronchitis cannot be easily appreciated, since high mortality and persistence of resistant pathogens beyond the first week despite treatment probably reflect the poor health status of these pts. Large scale studies are needed. DISCLOSURE: N.D. Manolakoglou, None. OBESITY AND THE OUTCOMES OF CHRONIC VENTILATOR DEPENDENCE Hasan M. Al-Dorzi, MD * ; Mary Ellen Kleinhenz, MD, FCCP. Division of Pulmonary, Critical Care and Occupational Medicine, Saint Louis University HSC, St Louis, MO PURPOSE: Obesity is a serious disorder with increasing prevalence. It is associated with multiple abnormalities in respiratory function that predispose to respiratory failure. This study assessed the prevalence of obesity among patients with chronic ventilator dependence CVD ; and evaluated the effect of BMI on their outcomes. METHODS: We performed a retrospective study of patients with CVD discharged from an LTAC facility between 3 01 01and Data collected included age, gender, ethnicity, height, weight, number of days on ventilator DOV ; , length of stay LOS ; , weaning success, mortality and disposition. RESULTS: We evaluated 141 patients with mean age of 69 14 yrs, mean BMI of 30 12, weaning success of 62% and mortality of 29%. We observed the following distribution of CVD patients among standard BMI categories: underweight BMI 18.5 ; 5%; overweight BMI 25 ; 63% and obesity BMI 30 ; 38%. Morbid obesity BMI 40 ; was present in 12% of patients, at a prevalence nearly 3 times that of the US population. Causes of CVD differed among the BMI categories: COPD in underweight patients OR 8.4, 95% CI 1.7-42.3, p 0.02 ; , major CNS event in obese patients OR 2.4 with 95% CI 1.02-5.70, p 0.06 ; and multiorgan failure in morbidly obese patients OR 4.8, 95% CI 1.6-13.8, p 0.005 ; . Morbidly obese patients were among the youngest CVD patients 61 12 yrs, p 0.01 ; . While LOS and DOV were not different from those of other patients, morbidly obese patients had the highest weaning success 76% ; , the lowest mortality 12% ; and were more likely to go home or to acute rehabilitation facility OR 3.9, 95% CI 1.3-11.9, p 0.02 ; . CONCLUSIONS: We observed an increased prevalence of morbid obesity among patients with CVD. Morbidly obese patients developed CVD at a relatively younger age often in association with multiorgan failure, but had a favorable prognosis. CLINICAL IMPLICATIONS: Critically ill patients with morbid obesity should be recognized as having high risk for CVD. A better understanding of obesity related respiratory dysfunction in the ICU setting would help to prevent this complication of critical illness. DISCLOSURE: H.M. Al-Dorzi, None. Substantial inter and intra observer variations in size of induration by customary palpatory method are found. The ball point method has the inherent problem of marking the skin with ink and possible skin injury irritation. Therefore a new method needs to be evolved for reading a tuberculin skin test. METHOD: A transparent scale was slided at an angle of 45 degree, starting 2cm away from the tuberculin skin test site. The scale stopped at the beginning of the site of induration due to resistance, slight pressure of the scale left the mark at the site of induration. This process was repeated to measure the transverse and horizontal indurations. The distance between the opposite marks was measured. Two readers measured the tuberculin readings using palpatory method, Ball point method and the New scale technique. They were blinded of each others readings. RESULTS: By palpation method, measurement from the second observer was observed to be 4.5 mm less to 3.5 mm more than the measurement from the 1st observer. Whereas using Ballpoint method and the New scale method the inter observer variation was much less i.e. 3mm less to 2.5mm more. The area of imprecision was much less broad for the ballpoint pen method and the new scale method then the palpation method. Intra observer variation between Ballpoint pen and palpation or New Scale Method and palpation method was wide whereas difference between Ballpoint pen method and New Scale Method was narrow. CONCLUSION: The inter and intra observer variations using New scale method are less then the customary palpatory method. The New scale method is useful for measuring tuberculin induration and eliminates the problem of soiling of the skin with the ink and possible injury while using ballpoint method. CLINCAL IMPLICATION: The New scale method can be employed for measuring tuberculin test indurations. DISCLOSURE: J. Kishan, None and
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Reference: 1. `Dear Healthcare Professional' letter from Boehringer Ingelheim, February 2004. Available from URL: : fda.gov 2. `Dear Healthcare Professional' letter from Boehringer Ingelheim, 20 February 2004. Available from URL: : hc-sc.gc.
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